1. Which of the following is NOT an NSAID?

A. Ibuprofen

B. Paracetamol

C. Naproxen

D. Diclofenac

Answer: B. Paracetamol

2. The primary mechanism of action of NSAIDs is:

A. Inhibition of dopamine receptors

B. Stimulation of opioid receptors

C. Inhibition of cyclooxygenase enzymes

D. Blocking sodium channels

Answer: C. Inhibition of cyclooxygenase enzymes

3. Which enzyme is primarily inhibited by NSAIDs to exert anti-inflammatory effects?

A. Lipoxygenase

B. Acetylcholinesterase

C. Cyclooxygenase (COX)

D. Monoamine oxidase

Answer: C. Cyclooxygenase (COX)

4. Which NSAID is known to be selective for COX-2 inhibition?

A. Ibuprofen

B. Celecoxib

C. Aspirin

D. Naproxen

Answer: B. Celecoxib

5. What is a common adverse effect of long-term NSAID use?

A. Constipation

B. Hyperglycemia

C. Gastric ulceration

D. Increased platelet count

Answer: C. Gastric ulceration

6. Which NSAID is used in low doses for cardioprotection?

A. Ibuprofen

B. Naproxen

C. Aspirin

D. Ketorolac

Answer: C. Aspirin

7. NSAIDs inhibit prostaglandin synthesis. Prostaglandins are synthesized from:

A. Cholesterol

B. Arachidonic acid

C. Amino acids

D. Glucose

Answer: B. Arachidonic acid

8. Which of the following NSAIDs is administered as an eye drop?

A. Indomethacin

B. Diclofenac

C. Naproxen

D. Etoricoxib

Answer: B. Diclofenac

9. The antipyretic effect of NSAIDs is due to:

A. Vasoconstriction

B. Inhibition of interleukin-2

C. Inhibition of prostaglandin synthesis in the hypothalamus

D. Increase in cortisol levels

Answer: C. Inhibition of prostaglandin synthesis in the hypothalamus

10. Which NSAID is considered safest for patients with cardiovascular risk?

A. Rofecoxib

B. Ibuprofen

C. Naproxen

D. Celecoxib

Answer: C. Naproxen

11. NSAIDs are contraindicated in:

A. Diabetes

B. Glaucoma

C. Peptic ulcer disease

D. Hypothyroidism

Answer: C. Peptic ulcer disease

12. Which NSAID has the longest half-life?

A. Ibuprofen

B. Naproxen

C. Diclofenac

D. Piroxicam

Answer: D. Piroxicam

13. The term “NSAID” excludes which class of drugs?

A. COX-2 inhibitors

B. Salicylates

C. Opioids

D. Propionic acid derivatives

Answer: C. Opioids

14. A major renal complication of NSAIDs is:

A. Diabetic nephropathy

B. Acute tubular necrosis

C. Interstitial nephritis

D. Hypertensive nephrosclerosis

Answer: C. Interstitial nephritis

15. Which NSAID is known to irreversibly inhibit COX-1?

A. Ibuprofen

B. Ketorolac

C. Aspirin

D. Celecoxib

Answer: C. Aspirin

16. Which of the following is a propionic acid derivative NSAID?

A. Indomethacin

B. Piroxicam

C. Ibuprofen

D. Aspirin

Answer: C. Ibuprofen

17. Rofecoxib was withdrawn from the market due to:

A. Hepatotoxicity

B. Skin reactions

C. Cardiovascular risks

D. Bone marrow suppression

Answer: C. Cardiovascular risks

18. NSAIDs should be used with caution in elderly due to:

A. Sedation

B. Hypoglycemia

C. Increased risk of GI bleeding and renal failure

D. Decreased absorption

Answer: C. Increased risk of GI bleeding and renal failure

19. Which NSAID is commonly used in dysmenorrhea due to its uterine selectivity?

A. Diclofenac

B. Mefenamic acid

C. Indomethacin

D. Ketorolac

Answer: B. Mefenamic acid

20. Which NSAID is commonly used as an analgesic in post-operative pain?

A. Piroxicam

B. Aspirin

C. Ketorolac

D. Naproxen

Answer: C. Ketorolac