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Back List of common kidney function tests 22 May, 2025

Sure! Here’s a  that help in clinical decision-making, along with their purpose and what they indicate:


1. Serum Creatinine

  • Purpose: Measures creatinine level in blood.

  • Indicates: Kidney filtration function; high values suggest impaired kidney function.

2. Estimated Glomerular Filtration Rate (eGFR)

  • Purpose: Calculated from serum creatinine, age, sex, race.

  • Indicates: Overall kidney function; lower eGFR means worse kidney function.

  • Used for: CKD staging and monitoring progression.

3. Blood Urea Nitrogen (BUN)

  • Purpose: Measures urea level in blood.

  • Indicates: Kidney function and hydration status.

  • Note: Can be elevated in dehydration or high protein intake, not just kidney disease.

4. Urinalysis (Routine Urine Test)

  • Purpose: Examines urine for protein, blood, glucose, sediments, cells.

  • Indicates: Signs of infection, inflammation, glomerular disease, or other abnormalities.

5. Urine Albumin (Spot Urine or 24-hour collection)

  • Purpose: Detects albuminuria, early kidney damage.

  • Indicates: Early kidney disease, especially in diabetes or hypertension.

6. Urine Creatinine (Spot Urine or 24-hour collection)

  • Purpose: Measures creatinine in urine.

  • Indicates: Used to normalize albumin or protein excretion; also evaluates muscle mass indirectly.

7. Albumin-to-Creatinine Ratio (ACR)

  • Purpose: Detects abnormal albumin excretion normalized to creatinine.

  • Indicates: Early kidney damage; preferred for screening diabetic nephropathy.

8. Protein-to-Creatinine Ratio (PCR)

  • Purpose: Measures total protein excretion normalized to creatinine.

  • Indicates: Degree of proteinuria, important for glomerular diseases.

9. 24-hour Urine Protein/Albumin Collection

  • Purpose: Quantifies total protein/albumin excretion.

  • Indicates: More accurate measurement of proteinuria than spot tests.

10. Renal Ultrasound

  • Purpose: Imaging to check kidney size, shape, obstruction.

  • Indicates: Structural abnormalities, obstruction, chronic damage.

11. Serum Electrolytes (Na, K, Cl, HCO3)

  • Purpose: Measures blood electrolytes.

  • Indicates: Kidney’s ability to regulate electrolyte balance and acid-base status.

12. Urine Microscopy

  • Purpose: Microscopic examination of urine sediment.

  • Indicates: Presence of red blood cells, white blood cells, casts, crystals suggesting specific diseases.

13. Cystatin C

  • Purpose: Blood marker of kidney function independent of muscle mass.

  • Indicates: Alternative to creatinine for estimating GFR.


Additional specialized tests (if needed):

  • Kidney biopsy: For diagnosing specific glomerular or interstitial diseases.

  • Serology: Autoimmune markers (ANA, ANCA, complement) if vasculitis or lupus suspected.

  • Imaging: CT scan or MRI if structural abnormalities or masses suspected.


Summary flow for clinical decision:

Step Test(s) Purpose
Screening Serum creatinine, eGFR, urinalysis, ACR Assess baseline kidney function and damage
Confirm proteinuria 24-hour urine protein/albumin, PCR Quantify protein loss
Assess structure Renal ultrasound Check for obstruction or anatomical issues
Evaluate cause Urine microscopy, serology, biopsy if needed Identify underlying kidney disease cause