Levodropropizine →
Peripheral antitussive
Suppresses dry cough without CNS depression.
Chlorpheniramine maleate →
First-generation antihistamine (H1 blocker)
Reduces allergic symptoms: runny nose, sneezing, watery eyes.
Has mild sedative effect.
Many coughs are allergic + irritative in nature (e.g., allergic rhinitis, seasonal flu).
Levodropropizine controls the cough reflex.
Chlorpheniramine reduces allergy-related symptoms (sneezing, nasal drip) that often trigger cough.
👉 Together: more effective relief in dry, allergic cough.
Dry cough associated with:
Allergic rhinitis
Upper respiratory tract infections (URTI)
Common cold with nasal allergy
Sometimes prescribed in bronchial irritation (but not asthma control).
From Levodropropizine → nausea, mild GI upset.
From Chlorpheniramine →
Drowsiness, sedation
Dry mouth, constipation
Blurred vision (rare)
Avoid in productive cough (can trap mucus).
Caution in:
Children <2 years
Elderly (due to sedation, confusion risk)
Patients with liver/kidney disease
Avoid driving/operating machinery (sedation risk from chlorpheniramine).
👉 Levodropropizine + Chlorpheniramine = Cough suppressant + Anti-allergy relief
Best suited for dry, allergic, irritative cough but not for wet cough.