Here's a clear and colorful breakdown of the Classification of Hypolipidemic Agents (Antihyperlipidemic Drugs) 🧬💊💥 — the medications used to lower lipid levels in the blood and reduce the risk of cardiovascular diseases ❤️🫀:

🌈 Classification of Hypolipidemic Agents 🌈

1️⃣ HMG-CoA Reductase Inhibitors (Statins) 💊🔧

📉 ↓ LDL, ↑ HDL, ↓ Triglycerides
🧪 Inhibit cholesterol synthesis in liver

• Atorvastatin

• Rosuvastatin

• Simvastatin

• Pravastatin

• Lovastatin

🟩 Most commonly used class

2️⃣ Fibrates (PPAR-α Agonists) ⚙️🔥

📉 ↓ Triglycerides, ↑ HDL
🧪 Stimulate lipoprotein lipase & fatty acid oxidation

• Gemfibrozil

• Fenofibrate

🟨 Used in hypertriglyceridemia

3️⃣ Bile Acid Sequestrants (Resins) 🧲🚫

📉 ↓ LDL
🧪 Bind bile acids in intestine → ↑ bile acid synthesis from cholesterol

• Cholestyramine

• Colestipol

• Colesevelam

🟧 Safe in pregnancy but cause GI side effects

4️⃣ Cholesterol Absorption Inhibitors 🛑🍔

📉 ↓ LDL
🧪 Inhibit absorption of dietary and biliary cholesterol

• Ezetimibe

🟦 Used with statins for additive effect

5️⃣ PCSK9 Inhibitors (Monoclonal Antibodies) 🧬🛡️

📉 ↓ LDL drastically
🧪 Promote LDL receptor recycling in liver

• Alirocumab

• Evolocumab

🟪 Used in familial hypercholesterolemia or statin intolerance

6️⃣ Nicotinic Acid (Niacin) 🌡️🌟

📉 ↓ LDL, ↓ Triglycerides, ↑ HDL
🧪 Inhibits lipolysis & hepatic VLDL synthesis

• Niacin (Vitamin B3)

🟥 Limited use due to flushing, hepatotoxicity

7️⃣ Omega-3 Fatty Acids 🐟💧

📉 ↓ Triglycerides
🧪 Inhibit VLDL production

• EPA + DHA (from fish oil)

🌊 Adjunct in hypertriglyceridemia

🧠 Mnemonic for Classification:

"Some Fatty Bunnies Eat Peanuts, Nuts, and Omega"
(S - Statins, F - Fibrates, B - Bile acid sequestrants, E - Ezetimibe, P - PCSK9 inhibitors, N - Niacin, O - Omega-3)Here's a clear and colorful breakdown of the Classification of Hypolipidemic Agents (Antihyperlipidemic Drugs) 🧬💊💥 — the medications used to lower lipid levels in the blood and reduce the risk of cardiovascular diseases ❤️🫀:

🌈 Classification of Hypolipidemic Agents 🌈

1️⃣ HMG-CoA Reductase Inhibitors (Statins) 💊🔧

📉 ↓ LDL, ↑ HDL, ↓ Triglycerides
🧪 Inhibit cholesterol synthesis in liver

• Atorvastatin

• Rosuvastatin

• Simvastatin

• Pravastatin

• Lovastatin

🟩 Most commonly used class

2️⃣ Fibrates (PPAR-α Agonists) ⚙️🔥

📉 ↓ Triglycerides, ↑ HDL
🧪 Stimulate lipoprotein lipase & fatty acid oxidation

• Gemfibrozil

• Fenofibrate

🟨 Used in hypertriglyceridemia

3️⃣ Bile Acid Sequestrants (Resins) 🧲🚫

📉 ↓ LDL
🧪 Bind bile acids in intestine → ↑ bile acid synthesis from cholesterol

• Cholestyramine

• Colestipol

• Colesevelam

🟧 Safe in pregnancy but cause GI side effects

4️⃣ Cholesterol Absorption Inhibitors 🛑🍔

📉 ↓ LDL
🧪 Inhibit absorption of dietary and biliary cholesterol

• Ezetimibe

🟦 Used with statins for additive effect

5️⃣ PCSK9 Inhibitors (Monoclonal Antibodies) 🧬🛡️

📉 ↓ LDL drastically
🧪 Promote LDL receptor recycling in liver

• Alirocumab

• Evolocumab

🟪 Used in familial hypercholesterolemia or statin intolerance

6️⃣ Nicotinic Acid (Niacin) 🌡️🌟

📉 ↓ LDL, ↓ Triglycerides, ↑ HDL
🧪 Inhibits lipolysis & hepatic VLDL synthesis

• Niacin (Vitamin B3)

🟥 Limited use due to flushing, hepatotoxicity

7️⃣ Omega-3 Fatty Acids 🐟💧

📉 ↓ Triglycerides
🧪 Inhibit VLDL production

• EPA + DHA (from fish oil)

🌊 Adjunct in hypertriglyceridemia

🧠 Mnemonic for Classification:

"Some Fatty Bunnies Eat Peanuts, Nuts, and Omega"
(S - Statins, F - Fibrates, B - Bile acid sequestrants, E - Ezetimibe, P - PCSK9 inhibitors, N - Niacin, O - Omega-3)